PROFILES

Prof. Andy Goren, MD, MD (hc)

President, Chief Medical Officer

Prof. Andy Goren has over 20 years of experience in research, development and commercialization of breakthrough therapeutics and diagnostics. Among the list of many firsts in dermatology, Prof. Goren was the first to develop a clinical genetic test for predicting androgenetic alopecia, the first to discover epigenetic markers predicting anti-androgen therapy response in female androgenetic alopecia, the first to develop a clinical acne vulgaris antibiotic response test based on P. Acnes bacterial genomics, and the first to develop a rapid test for predicting minoxidil response in androgenetic alopecia.

Prof. Goren is actively involved in the development, commercialization, and listing of several drugs and medical devices including new therapies for female pattern hair loss, chemotherapy induced alopecia, excessive hair shedding, female sexual dysfunction and COVID-19. His latest research involves the use of anti-androgen therapy for the treatment of COVID-19.

Prof. Goren currently serves as an External Medical Advisor and a Co-Researcher, Trichology Unit, Ramon y Cajal Hospital, Madrid, Spain, a Visiting Professor of Dermatology, Department of Dermatology and Venereology, Clinical Hospital Center Sestre Milosrdnice, Zagreb, Croatia, a Medical Doctor at the Skin & Cosmetic Research Dept., Shanghai Skin Disease Hospital, Shanghai, China and a Visiting Medical Doctor, Department of Dermatology and Venereology, L.T.M. Medical College Sion, Mumbai, India. Clinical Research Director at Samel Hospital, Manaus, Brazil. Prof. Goren has published dozens of peer-reviewed original medical research papers. He is an honorary as well as ordinary member of several dermatology societies world-wide as well as a regular lecturer at dermatology congresses around the world. He held numerous appearances and interviews on mainstream TV, radio, and prestigious newspapers.


Sharon Keene, MD

Medical Director

Dr. Sharon Keene is a board certified general surgeon, who completed her surgical training at the University of Arizona in Tucson. She has subsequently specialized in the medical and surgical treatment of hair loss for men and women.

For the past 2 decades she has gained professional acclaim, using her surgical knowledge to advance techniques and improve cosmetic outcomes. Dr. Keene has shared her expertise through lecturing, teaching and authorship of medical articles and has received many professional awards for her work in hair restoration. She has been actively involved in research to improve diagnosis and treatment of female hair loss, by co-developing and co-authoring a pilot study on epigenetic influences on the androgen receptor gene and response to finasteride therapy in female hair loss. Since the completion of that project, she has written and lectured on the various environmental and dietary influences that may be affecting human epigenetics and increasing the rate and expression of androgenetic alopecia. Additionally, Dr. Keene has developed surgical instruments and tools to improve the ergonomics and efficiency of surgery.

As part of her commitment to peer education, she has participated in various capacities and on various educational committees for the International Society of Hair Restoration Surgeons (ISHRS) including: scientific chairman for the annual scientific committee (2007), chairman of the evidence based medicine task force (2009-10), member continuing medical education committee, current chairman of the finance committee and member of the expert subcommittee panel on best practices. She is currently the treasurer and an active member of the ISHRS executive committee. Dr. Keene served as chief medical officer for Dermagenoma from 2008-11, a medical genomics company which provided genetic tests related to diagnosis and treatment of dermatologic and associated conditions such as androgenetic alopecia, psoriatic arthritis, etc. She also serves in a pro bono capacity as a member of the health authority advisory board to a small rural clinic, Elbowoods Memorial Health Center, in North Dakota. She currently practices hair restoration surgery at Physician’s Hair Institute in Tucson, AZ.


John McCoy, PhD

Vice President, Research & Development

Dr. John McCoy is head of the research and development team at Applied Biology. He has over 15 years of laboratory research experience at many of California's premier institutions, including UCLA, UCSD and UC Berkeley.

Dr. McCoy spent his academic career developing novel instrumentation and scientific methodology to measure biophysical properties of proteins. He pioneered the novel techniques of high-pressure electron paramagnetic resonance spectroscopy and high-pressure circular dichroism. He has utilized his strong background in biophysics to develop creative solutions to topical drug development.

Currently, Dr. McCoy's research is focused on the development of novel topical drugs for application in many fields including dermatology, women’s health, and oncology.

Dr. McCoy has authored several original patents and scholarly articles for publication in peer-reviewed scientific journals. He is a member of the American Chemical Society, the Biophysical Society, and the Society for Investigative Dermatology. Dr. McCoy was a postdoctoral fellow at the Jules Stein Eye Institute (UCLA) where he was the recipient of the prestigious Gerald Oppenheimer Post Doctoral Fellowship and the National Institutes of Heath Vision Science Training Grant.


Monica Naegle

Director of Finance and Operations, International and Business Development

Monica Naegle is Applied Biology’s Director of Finance and Operations, International and Business Development. Ms. Naegle oversees day-to-day business operations, guides investment and business development decisions both internationally and domestically, and supports and develops the necessary framework for marketing efforts and all project management. She is responsible for overseeing Applied Biology’s product R&D and shaping the company’s long-term fiscal and operational manufacturing strategies. Additionally, Monica plays a key roll in the implementation and compliance of Applied Biology’s clinical studies. Her clinical study engagement spans subject screening, consent and registration, compilation and submission of data, monitoring of study compliance, and maintenance of data submission system.

Ms. Naegle joined Applied Biology in 2011 with 30 years experience in business, spanning finance, manufacturing, airline, hospitality, engineering, security, and construction industries. Monica grew up speaking, reading and writing both English and Castilian Spanish and maintains fluency in both languages today. On her off time, Monica is pleasantly busy with two teenage girls, attending dance competitions or functions and water polo games. Ms. Naegle earned a Bachelor of Science Degree in Business with an emphasis in Math from the University of California, San Diego.


Flavio Cadegiani, MD, PhD

Clinical Director

Flavio Cadegiani, MD, PhD, is a board certified endocrinologist with MSc and PhD degrees in Clinical Endocrinology, with two concurrent careers, in the university and in private practice.

Dr. Cadegiani researches on fatigue-related conditions resulted in the article (“Adrenal Fatigue Does Not Exist: A Systematic Review”, published at the BMC Endocrine Disorders) that has become a world reference to debunk the existence of "Adrenal Fatigue", a fake disease, as mentioned in The Washington Post. In his studies, he realized different unrelated states that were markedly affected by fatigue had methodological issues in the assessment of hormones and metabolic parameters, and could have pathophysiological correlations between them. Among these states, he was called special attention for overtraining syndrome, for which endocrinology aspects were claimed to be central for the occurrence and as a major manifestation in this disease.

By addressing methodological issues on hormonal research, and aiming to answer the major questions on overtraining syndrome, as well as on healthy athletes, he conducted as the principal investigator the largest clinical study on the Endocrinology of Physical Activity, the Endocrine and Metabolic Responses on Overtraining Syndrome (EROS) study. The EROS study evaluated more than 110 parameters within more than 50 participants, including two control groups, that revealed multiple novel biomarkers and mechanisms not only in overtraining, but also in healthy athletes, and has been unfolded in more than 10 published papers.

In the EROS study, Dr. Cadegiani discovered the existence of a novel mechanism that occurs in physically active subjects, termed as 'hormonal conditioning', by proving that hormonal axes have optimized responses to any type of stimulation, not restricted to physical effort, which may justify several of the benefits found in athletes that were not clarified until then. He has discovered more than 45 biomarkers in overtraining syndrome, and created the first validated scores for the diagnosis of Overtraining Syndrome. He proposed a new model of understanding underperformance-related syndromes, coining the term 'Paradoxical Deconditioning Syndrome (PDS)', since the hallmark characteristic that he identified in athletes that lost performance was the loss of the conditioning processes that occur in several systems in athletes.

His multiple discoveries include the testosterone-to-estradiol ratio, as being a better predictor of multiple clinical and biochemical behaviors, rather than each hormone alone, opening doors to the hormonal balance era, instead of isolated analyzes. He also unraveled that prompt hormonal responses to stimulations predict the ability for explosive physical responses, whereas prolonged hormonal responses predict longer time-to-fatigue in sports. e helped raise the amount of protein intake necessary for athletes.

Dr. Cadegiani has become a worldwide expert in both Endocrinology and Sports Medicine fields, providing a unique endocrinological perspective to Physical Activity.

Dr. Cadegiani is the only author of the sole book in Overtraining Syndrome, the prevailing sport-related disease among amateur and professional athletes. He is also responsible for approximately 70% of the articles published in the field in the world in the last 05 years, and reviewer for more than 90% of the manuscripts in the field.

Dr. Cadegiani research fields go beyond fatigue and related conditions. He is a worldwide known expert for obesity management, amongst the largest experts in pharmacological weight loss management, and the creator and of the first scientifically proven effective therapy to prevent bariatric surgery in morbidly obese subejcts.

Dr. Cadegiani contributions to the obesity field also include the first chapter fully dedicated to describe the dysfunctions of the liver in obesity and responses to bariatric surgery. the first drug to reduce early and late Dumping's syndrome after bariatric surgery, and has now demonstrated paradoxical weight loss markers, including increased homocysteine and triglycerides, which usually are considered as being negative parameters, but represent positive correlation with fat loss.

Currently Dr. Cadegiani has a position at Federal University of São Paulo as a mentor of the MSc and PhD programs in Clinical Endocrinology. He obtained his medical degree in University of Brasilia in 2008, finished his residency in internal medicine in the same university in 2010 and fellowship in Endocrinology and Metabolism in HBDF, Brasilia, Brazil, in 2012.

His superlative achievements include amongst the fastest PhD obtained in the history of Federal University of São Paulo (7 months) and concurrent gold medals in Mathematics, Chemistry and Physics Brazilian Olympics in his adolescence.

Dr. Cadegiani believes that there is much to discover in the world of androgens and skin-related diseases, and how skin and hair can provide a deeper and more precise steroidal and metabolic mapping, particularly in the long term, in contrast to the snapchat sort of analysis of blood samples. He wants to expand the understanding of the multiple crosstalks between skin and hormones, and describe a thorough characterization of the peculiarities of the steroidal steroidogenesis in the hair and skin, as well as the implications for diagnoses and therapeutics.


Maja Kovacevic, MD

Clinical Researcher

Maja Kovacevic, MD graduated at School of Medicine University of Zagreb, Croatia in 2012. In 2013 she attended Postgraduate academic study "Biomedicine and Health Sciences" at University of Zagreb, School of Medicine, Zagreb while her PhD thesis in vitiligo research area was accepted in 2015. During 2015 she starts working at Department of Dermatology and Venereology, University Hospital Center Sestre milosrdnice, Zagreb as dermatovenerology resident. Thorough clinical and scientific work, her main point of interest are trichology and pigmentary disorders. As an invited speaker, she actively participated in international scientific congresses in Tel Aviv, Cannes, Dubai, Bengaluru, Kyoto and also attended trichoscopy courses in Warsaw and Bolognia, onychoscopy course in Bologna and melanocyte transplantation education in Chandigarh, India. Before starting and during her residency she is active in research work as author and co-author of 13 papers in indexed journals and dermatovenerology book chapters published by Croatian and international publishers. She is a member of European Academy of Dermatology and Venerology (EADV), European Hair Research Society (EHRS), International Society of Dermatology (ISD), International Dermoscopy Society, Croatian Dermatovenerological Society, and works as a secretary of Croatian Vitiligo Association.


Marissa Li, MD

Laboratory Director

Marissa Li, MD completed her bachelors of sciences degree in neuroscience at UCLA in 2001. Continuing her studies at UCLA she completed her MD degree in 2005. Following one year of internal medicine internship at Kaiser Permanente Hospital, Los Angeles she then completed a pathology residency at Cedars Sinai Medical Center in Los Angeles. Dr. Li subsequently obtained two years of transfusion medicine training both at Cedars Sinai Medical Center and UCLA Medical Center. She is the CLIA lab director of several high complexity clinical laboratories in California and Nevada. She has published numerous scientific articles/book chapters in the area of transfusion medicine/immunology.




FUTURE DERMATOLOGIST

Eli Goren

Eli Goren

Future Vice-President of Applied Biology and Head of Dermatology in Florence

Eli Goren has his whole life of experience in research and is amazing with technology, and also, is very helpful is very capable of technology and Medical Engineering.

Also, he is capable of many more things he has hobbies including, games, sports, horseback riding, technology, and so much more! He can also help out so much with the business including, technology, medical services, and much more. He is helpful, kind, and always has a smile on his face. He will help with as much as he can in the business and much more he will put in his 1000% effort if not much more! He will do anything for this business and to keep it running and to help launch it.

Lastly, Eli Goren will do whatever it takes to keep this business going and make sure it stays going and keeps launching more products so the business is staying in check he will do whatever it takes.